GSK reports promising early results in ovarian and womb cancer drug trial

GSK has revealed positive results for a treatment for gynaecological cancers as its chief executive, Luke Miels, seeks to speed up drug development at the group.The company said that in an early-stage trial Mocertatug Rezetecan, known as Mo-Rez, shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.Based in London, GSK has recently gained plaudits for its work on tackling superbugs, becoming one of just three big pharma companies globally that continue to invest in anti-microbial research.However, commercially GSK has been eclipsed in recent years by its bigger British rival AstraZeneca, which last year outstripped GSK’s near-£33bn turnover by more than £10bn and whose market value is more than twice as high.GSK acquired the Mo-Rez cancer treatment, an antibody-drug conjugate (ADC), from China’s Hansoh Pharma in late 2023, and has trialled it in 224 patients around the world, including the UK, over the past year

Collapse of US-Iran talks heightens fears of prolonged energy shock

The failure of the US and Iran to reach a peace deal after marathon negotiations has put markets on alert for further oil and gas price rises.With large numbers of oil tankers remaining stuck in the Gulf, the US vice-president, JD Vance, blamed the collapse of the talks on Tehran’s refusal to abandon its nuclear weapons programme, while Iranian sources hit back at “excessive” demands from Washington.Vance, who left Islamabad on Sunday morning after 21 hours of talks with Iranian officials in the Pakistani capital, said his team had been very clear on its red lines as hopes faded of a quick end to the war that began on 28 February with US and Israeli airstrikes on Tehran.A weekend market in US crude oil operated by the broker IG indicated that the oil price was going to rise when trading begins on Sunday night, UK time, to about $98 a barrel, from about $96.50 on Friday night before the peace talks in Pakistan

AI companies know they have an image problem. Will funding policy papers and thinktanks dig them out?

OpenAI made a surprise announcement this week – not an update to ChatGPT or another multibillion-dollar datacenter – but a policy paper that called for a reimagining of the social contract based around “a slate of people-first ideas”. It’s the latest move in an aggressive effort by the major AI players to reshape the narrative around their industry, as polls show public disapproval of AI increasing.OpenAI’s 13-page paper, titled Industrial Policy for the Intelligence Age, follows its surprise acquisition of tech-friendly podcast TBPN and its announcement of plans to open a Washington DC office that will feature a dedicated space called the OpenAI workshop for non-profits and policymakers to learn about and discuss the company’s technology.OpenAI’s rival Anthropic has meanwhile announced its own thinktank, the Anthropic Institute, which similarly proclaimed an intention to explore how the growth of AI would disrupt society.As disruptions from AI become more tangible and calls for greater scrutiny of big tech companies grows louder, the industry appears to be both recognizing the widespread discontent and looking for ways to reframe the debate

‘Too powerful for the public’: Inside Anthropic’s bid to win the AI publicity war

This week, the AI company Anthropic said it had created an AI model so powerful that, out of a sense of overwhelming responsibility, it was not going to release it to the public.The US treasury secretary, Scott Bessent, summoned the heads of major banks for a chat about the model, Mythos. The Reform UK MP Danny Kruger wrote a letter to the government urging it to “engage with AI firm Anthropic whose new frontier model Claude Mythos could present catastrophic cybersecurity risks to the UK”. X went wild.Others were more sceptical, including the noted AI critic Gary Marcus, who said: “Dario [Amodei] has far more technical chops than Sam [Altman], but seems to have graduated from the same school of hype and exaggeration,” referring to the CEOs of Anthropic and its rival, OpenAI

Is Gout Gout faster than Usain Bolt? Australian sprinter sets sights on Jamaican great’s 200m record

Having cracked the 20-second barrier with a sizzling run over 200m – and in the process fulled comparisons with the great Usain Bolt – the question now is, how fast can Gout Gout go?“How long’s a piece of string?” said Gout’s coach and mentor, Di Sheppard, after he clocked 19.67sec at the Australian championships in Sydney on Sunday.The time smashed his own national record of 20.02sec and was good enough for him to become the first Australian to record a legal time under the magical 20-second barrier.Aidan Murphy quickly became the second, just a step behind with another supremely impressive run in the same race, but Gout grabbed the headlines as he bettered Bolt’s best when the Jamaican sprint great was the same age

Rory McIlroy targets even loftier goals after winning back-to-back Masters titles

Rory McIlroy has warned the rest of elite golf he will set further, lofty goals in his sport after a successful defence of the Masters.McIlroy prevailed at Augusta National by a shot over Scottie Scheffler, meaning the Northern Irishman becomes just the fourth golfer in history to win the tournament back-to-back. While McIlroy will cherish his win, he has no plans to rest on his laurels.“I just won my sixth major and I feel like I’m in a really good spot with my game and my body,” McIlroy said. “I don’t want to put a number on it, I don’t want to say a stop on the journey, but it’s just a part of the journey